Type 2 Diabetes is coupled with a range of microvascular and macrovascular complications Type 2 diabetes is associated with the following long-term complications: …
Diabetes in Western European Nation
Life Sciences
Objective: Conduct a quick-cycle study for a Life Sciences Company to evaluate the economic toll that diabetic complications have on a Western European Nations healthcare system Role of Grail Research: Leveraged industry-specific expertise and local language resources to provide a fresh, objective perspective on this issue despite a compressed timeline
Gathered data from countryspecific sources
Interviewed industry-experts to fill any data gaps
Analyzed all collected data and presented final output
1 day
2 days
1 day
|
Copyright 2007 Grail Research, LLC — Confidential
1
Diabetes in Western European Nation
Prevalence of Type 2 Diabetes
The Type 2 diabetic population in a Western European Nation has grown steadily from 2003-2005
Prevalence of Type 2 Diabetics in Western European Nation Source A Statistical Data 20YY
Population XX Million
Millions
CAGR X
Total Diabetics X Million
2003
2004
2005
2006E 2007E 2009E 2011E 2013E 2021E
Type 1 Diabetics X Million
Type 2 Diabetics X Million
Prevalence of Type 2 Diabetics in Western European Nation Other Sources
Other Facts XX of the type 2 diabetics are in the normal
weight category, XX are overweight, XX are obese and X display morbid obesity The prevalence of arterial hypertension HTA in Type 2 diabetic patients is XX The prevalence of amputations in Type 2 diabetic patients is X
Millions
C A GR
X
2003
2004
2005
2006E 2011E 2016E 2021E 2026E 2030E
|
Copyright 2007 Grail Research, LLC — Confidential
2
Diabetes in Western European Nation
Cost of Type 2 Diabetes Study 20YY
In the Western European Nation, drugs accounted for the greatest healthcare costs XX, followed by hospital care XX, and ambulatory care XX
The study was conducted in 20YY to measure the total healthcare costs of Type 2 diabetes in Europe It evaluated over 7000 Type 2 diabetic patients across 8 European nations
Information on Western European Nation Study
Prevalence of Type 2 diabetes: XMM patients X of population Percentage of patients hospitalized in the six-month study period: X Average length of stay per hospitalization: X days Demographic data: Average age in years: XX Male / Female : XX / XX 2: XX Mean BMI kg/m Mean time since diagnosis in years: XX XX
Per Patient Costs
Oral antidiabetic drugs Other Drugs Hospitalization
National Costs For
Resources
General practitioner visit: EUR XX Diabetologist visit: EUR XX Other visit: EUR XX-XX Paramedical visit: EUR XX-XX
Ambulatory Care
Physiotherapist: EUR XX Nurse: EUR XX-XX Footcare: EUR XX
ICU: EUR XX Ward: EUR XX Annual Direct Medical Cost Per Patient: EUR XX Emergency: EUR XX-XX
The total annual direct health care costs of Type 2 diabetes in the Western European Nation were EUR XX Bn in 20YY
|
Copyright 2007 Grail Research, LLC — Confidential
3
Diabetes in Western European Nation
Cost of Diabetes Department of Economics Study
As per estimates, diabetic patients consume 5-6 of the healthcare expenditures in the developed countries
Following are the findings of the study conducted by Department of Economics University A Other Data Points from the Study
Costs of Diabetic Patients, 20YY
Cost of Diabetes Mellitus Type1 Type2 EUR MM
Cost of Insulin Oral Hypoglycemic Agents Other Drugs Consumable Goods Visit to Specialists Dialysis Primary Care Visits Hospital Costs Total cost A XX XX XX XX XX XX XX
Estimated Cost of Type 2 Diabetes EUR MM
XX XX XX XX XX XX XX
Key Findings: In YYYY, the total costs associated with diabetes were nearly EUR XXMM, with an
average cost of EUR XX per patient annually Hospitalization costs represented a major portion of all costs XX, followed by doctor and hospital outpatient visits XX, antidiabetes drugs XX, laboratory tests XX, and dialysis X The direct health care costs of diabetes were EUR XXMM, or EUR XX per patient annually XX of the total cost of a diabetic patient The indirect health care costs were EUR XXMM XX of the total cost
Diabetes Mellitus Patients B Per Patient Cost EUR A/B
XX XX
XX XX
Source: Study conducted by Department of Economics University A; Grail Analysis
| Copyright 2007 Grail Research, LLC — Confidential
4
Diabetes in Western European Nation
Complications Across 7 major markets
Type 2 Diabetes is coupled with a range of microvascular and macrovascular complications
A physician survey for Type 2 Diabetes revealed that in 20YY, an average of XX of diagnosed Type 2 diabetes patients across the seven major markets have complications Type 2 diabetes is associated with the following long-term complications:
Microvascular complications: Includes nephropathy, retinopathy and neuropathy Survey results generated by extensive clinical checks indicate an average of XX of Type
2 Diabetic patients have microvascular
complications
Macrovascular complications: Includes atherosclerosis, coronary artery disease, stroke and peripheral vascular disease Checks with clinicians suggest that an average of XX of Type 2 Diabetic patients have macrovascular complications
Microvascular Complications across seven major markets
Nephropathy: Characterized by weakening of kidneys ability to properly filter circulating blood Among the diagnosed Type 2 diabetic patients: XX have microalbuminuria, XX have proteinuria, and X have end-stage renal disease Retinopathy: Characterized by a broad range of ophthalmologic problems caused by hyperglycemia Among the diagnosed Type 2 diabetic patients: XX have retinopathy Neuropathy: Characterized by development of temporary or permanent damage to nerve tissue due to hyperglycemia and decreased blood flow Among the diagnosed Type 2 diabetic patients: XX have neuropathy
Macrovascular Complications across seven major markets
Macrovascular complications include cardiovascular disease, stroke, myocardial infarction MI, and coronary artery disease CAD Among the total diagnosed Type 2 diabetic 
patients: XX, XX, and XX have suffered
stroke, MI, and CAD respectively
|
Copyright 2007 Grail Research, LLC — Confidential
5
Diabetes in Western European Nation
Costs Associated with Complications
Microvascular complications, such as Nephropathy, Retinopathy, and Neuropathy account for a majority of complications in Type 2 Diabetic patients
Nephropathy
In 20YY, direct costs associated with renal complications in the Western European Nation were:
Retinopathy
In 20YY, following were the direct costs associated with ophthalmologic complications in Western European Nation:
Annual haemodialysis cost: EUR XX Annual peritoneal dialysis cost: EUR XX Annual renal transplantation cost: EUR XX
In 20YY, the average cost of treatment with dialysis in the Western European Nation was between EUR XX and XX for each session
Laser treatment cost: EUR XX Cataract operation cost: EUR XX Annual cost following cataract operation: EUR XX
Neuropathy
In 20YY, following were the direct costs associated with Neuropathy and Foot Ulcers in Western European Nation:
Other Complications
In 20YY, direct costs associated with other diabetic complications in the Western European Nation were:
Annual neuropathy cost: EUR XX Lower
extremity amputation cost: EUR XX Prosthesis: EUR XX Gangrene treatment: EUR XX
Annual myocardial infarction cost: EUR XX Annual coronary heart failure cost: EUR XX Annual stroke cost: EUR XX Annual angina cost: EUR XX Cost of hypoglycemic events requiring medical assistance or resulting in coma/seizure: EUR XX
Cost of ketoacidosis/lactic acid events: EUR XX
|
Copyright 2007 Grail Research, LLC — Confidential
6
Diabetes in Western European Nation
Anti-Diabetic Sales Forecast in the Western European Nation
The anti-diabetic market in the Western European Nation is dominated by the Sulfonylureas class which includes brands such as Brand 1, Brand 2 etc
Anti-Diabetic Sales Forecast in the Western European Nation, 20052015E
Brand 3 Brand 2 Brand 4 Brand 5 Brand 6 Brand 1 Generics
USD MM
2005
2007E
2009E
2011E
2013E
2015E
|
Copyright 2007 Grail Research, LLC — Confidential
7
Diabetes in Western European Nation
Price Comparison of Major Anti-Diabetics
Price Comparison of Major Anti-diabetics
Drug
Brand 1
Molecule/Class
GLIMEPIRIDE
Specification
X mg / XXX Capsules X mg / XXX Capsules XX Capsules
Retail Price
EUR XX EUR XX EUR X
Brand 2
GLICLAZIDE
Brand
3
GLIBENCLAMIDE
X mg / XXX Capsules XX mg / XX Capsules
EUR X EUR XX EUR XX EUR XX EUR XX EUR XX EUR XX EUR XX
Brand 5
PIOGLITAZONE
XX mg / XX Capsules XX mg / XX Capsules XX mg / XX Capsules X mg / XX Capsules
Brand 4
ROSIGLITAZONE
X mg / XX Capsules X mg / XX Capsules
Source: Grail Primary Research
| Copyright 2007 Grail Research, LLC — Confidential
8
Diabetes in Western European Nation
Pre-diabetes
About XX XX of people with pre-diabetes will develop type 2 diabetes in next X years
Pre-diabetes is an early stage of diabetes, where the level of glucose in the blood becomes higher than normal, but not high enough to be diagnosed with diabetes Pre-diabetic patients are at increased risk of developing type 2 diabetes and cardiovascular diseases In Europe, over XX million people 8 of total population are estimated to have pre-diabetes and a vast majority of these people are ignorant of their condition In the Western European Nation, IGT Impaired Glucose tolerance prevalence is X of population and IFG Impaired Fasting Glucose prevalence is X of population
Prediabetes
Diagnosis Tests for Pre-diabetes Fasting Plasma Glucose FPG
FPG test measures the amount of glucose
remaining in the blood when the person has not had food or drinks for at least 8 hours Diagnostic criteria for pre-diabetes and diabetes based on FPG level:
Oral Glucose Tolerance Test OGTT
OGTT measures the amount of glucose in the blood when the person has not had food or drinks for at least 4 hours The level is recorded both before and after 2 hours when the person has eaten food containing specific amount of carbohydrates Diagnostic criteria for pre-diabetes and diabetes based on OGTT:
126 mg/dL: Diabetes 100 mg/dL and 126 mg/dL: Pre-diabetes 100 mg/dL: Normal If FPG level 100 mg/dl, patient is referred to have IFG
200 mg/dL: Diabetes 140 mg/dL and 200 mg/dL: Pre-diabetes 140 mg/dL: Normal If OGTT level 140 mg/dl, patient is referred to have IGT
|
Copyright 2007 Grail Research, LLC — Confidential
9
Diabetes in Western European Nation
Ethnic distribution of total population
People from Regions 3, 4, 5 and 6 have higher risk of pre-diabetes
Place of Origin
Europe excluding the Western European Nation Western European Nation Region 1 Region 2 Region 3 Region 4 Region 5 Region 6 Total
Population
XXX
of total population
404
Ethnic Distribution of Western
European Nation Population, 20YY
6
XXX XXX XXX XXX XXX XXX XXX XXX
8918 189 045 018 372 054 001 10000
4
398
Population MM
2
18
16 084 024 02 008 0006
0
Western European Nation Region 5 Region 6
Region 4 Region 7
Europe excl Western Region 2 European Nation
Region 3
|
Copyright 2007 Grail Research, LLC — Confidential
10
Project Results
Research Challenge
Life Sciences company sought a current, comprehensive account of Diabetic complications impact on a Western European Nations healthcare system Life Sciences entity did not possess the linguistic capabilities and the resources required to generate this perspective
How Grail Research Delivered
Conducted research and interviews geared to identify and synthesize critical market intelligence from a number of disparate sources published in local language Armed Life Sciences Entity with a fresh, thorough assessment of Diabetes impact on a Western European Nations healthcare system despite compressed timeline Client pursues research relationship with Grail Research
|
Copyright 2007 Grail Research, LLC — Confidential
11
