Twenty five children with type 1 diabetes were examined. In the children with type 1 diabetes we have also observed the decrease of …
ENDOGENOUS INTOXICATION IN CHILDREN WITH TYPE 1 DIABETES
KireevRA1, Kurmacheva NA2, Marianovsky AA3
Dep Biochemistry State University 1, Saratov Juvenile Endocrinology Centre
2, Medical Center 3, Moscow, Russia
The objective of the given investigation was the study of metabolic
disorders that children with type 1 diabetes develop Twenty five children
with type 1 diabetes were examined The patients were divided into three
groups according to the duration of the illness: the first group consisted
of nine children in which the period of manifested diabetes lasted no
longer than one year 1-12 months; the second group consisted of
nine children with the duration of the illness from 1 to 5 years; and the
third group consisted of seven children with the duration of illness from 8
to 12 years
The criteria for endogenous intoxication were the determination of
substances with low and average molecular mass The method consisted of
precipitating the large-molecule particles of plasma and erythrocytes by
means of trichloroacetic acid solution 150 g/l and water solution in the
zone of wave-length from 238 to 310 nm on the
spectrophotometer It was
found that in patients of all the 3 groups there occurs the accumulation of
catabolism products in plasma In the 1st group the catabolism pool was
55; in the 2nd group it was 49 and in the 3rd group it was 38,5 In the
control group catabolism products make up 15 It suggests the fact that in
patients with diabetes of a duration no longer than 1 year there occurs a
sharp disorder of metabolic processes and in plasma there accumulates the
products of tissue cell decay and catabolism products With increased
duration of the illness possibly compensatory mechanisms start to work and
the content of catabolism products decreases It has also been observed
that with the increase duration of the illness in children with type 1
diabetes there occurs a disorder of erythrocytes, glycocalix, that is
proved by the re-distribution of substances with low and average molecular
mass between erythrocytes and plasma In the 1st group K1pl/er0,758, in
the 2nd-group K2pl/er1,0142 and in the 3rd K3pl/er1,0409 with the
control value of Kpl/er0,5 It suggests the disorder of sorbing ability of
erythrocytes It is important to
note that the disorder of erythrocytes,
glycocalix occurs when the duration of illness increases
In the children with type 1 diabetes we have also observed the decrease of
guanosine, desoxyadenosine acid, adeninedesoxyriboside and a contain
increase of uracil,UTP, UDP in erythrocytes With the increase of illness
duration, in plasma there occurs an increase of inosine, ryptamine content,
but their value remains lower than the control value
Keywords: diabetes, intoxication, metabolic processes, glycocalix
KireevRA@infosguru
Source:tiaft.org
