The synergistic effect of diabetes mellitus and its associated disease have recently to this global epidemic, the Research Unit of the University Diabetes …
University Diabetes Center
Research Department
University Diabetes Center
Introduction:
The synergistic effect of diabetes mellitus and its associated disease have recently increased their debilitating impact and in the kingdom of Saudi Arabia as well
In response to this global epidemic, the Research Unit of the University Diabetes Center has taken a step further in creating various specialties through extensive scientific researches that would cater to the increasing needs of its growing diabetic population Equipped with competent staff and state of the art equipments from both medical and scientific sectors, the Research Unit is more than ready not only to lead the campaign against diabetes in the kingdom but also to pioneer new knowledge and understanding of the disease in the Arab World for better quality care and medical of diabetes
University Diabetes Center
University Diabetes Center
University Diabetes Center
Objectives:
To conduct relevant scientific research studies that revolves around diabetes, its complications, associated diseases and risk factors
To develop a conducive research environment that encourage researchers to participate and be part of the team
as well as promote academic excellence as a learning institution
Encourage medical, pharmaceutical and other sectors to invest in the research center in the form of grants and encourage other institutions to form scientific collaborations in various research activities
To be a leading Arab institute in diabetes research that is at par with other diabetes research institutions worldwide
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Achievements: Total Number of the Projects
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Total Number of Ongoing Projects- 18
Total Number of Projects About To Commence 5
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Conferences Attended and Participated
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Papers Published
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Future Plan:
1- To be the leader institute in conducting studies in diabetes and each complication 2- To be reliable scientific information source for all medical institute in the field of diabetes 3- To be an important factor helping in developing patients medical case strategies in the field of diabetes 4- To build a laboratory with new equipment 5- To be able to analyze all types of parameters 6- To be able to publish every month two scientific papers 7- To be recognize
institution nationally and internationally as an authority in diabetes research 8- To open other branches in other cities and countries around the globe
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Data 2007: Projects we have
On-going Epidemiology Clinical Research
Diabetes Impact in Saudi Health [Epidemiology Clinical Research] a Prevalence of diabetes among Saudi children b Prevalence of diabetes among Saudi adults c Economic impact of diabetes d Geographical map in the kingdom
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On-going Basic Research
Insulin resistance, adverse metabolic profile and premature biological aging in overweight children [Basic Research]
Objective:
Primary Objective:
1- Assess for the time adipocytokines profile and premature biological aging in overweight children 2- To evaluate the relationship of these profiles to the development of insulin resistance 3- Determine the influence of physical activity, diet and association of metabolic risk both children and parents profile Secondary Objectives: We will be able to relate rate of loss of telomere length measure of bilogiocal age to serum and obesity in parents and children
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GSSD study of the family with
type1 DM, of type2 DM above 60 years old, of control above 60 years old Genetic Study in Saudi Diabetic Patient GSSD
[Basic Research]
Objective: Genetics and basic science in diabetes to identify regions in the human genome within which genes predisposing to with diabetes mellitus in the Saudi population
Silent Myocardial Ischemia in Patients with Diabetes Mellitus
Objective: To detect silent Myocardial Ischemia in type 2 diabetic patients in local population, considering the diabetes mellitus as a major health problem in Saudi Arabia The purpose of this 1-year study was to estimate the prevalence of SMI and define a high risk diabetic population by systematically testing patients with no symptoms of CAD in order to detect the disease early and to treat appropriately as to reduce the CV mortality rate [Basic Research]
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Effect of the Ramadan fast on protein damage and antistress response gene expression in type 2 diabetic patients and normal healthy controls
[Basic Research] Objectives: 1 To assess changes in plasma and urinary markers of protein damage by glycation, oxidation and nitration at before, during and after the Ramadan fast 2 To study changes
in anti-stress gene expression in human mononuclear leukocytes before, during and after the Ramadan fast 3 To study clinical indicators of glycaemic and metabolic control and risk markers of vascular disease before, during and after the Ramadan fast 4 To study the association of markers of protein damage and anti-stress gene response to biomarkers of biochemical and vascular dysfunction before, during and after the Ramadan fast
On-going Pharmacology Research
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Bioequivalence study
Clinical Trial A: A prospective, randomized, and Double Blind comparative study of Jusline insulin vs other types of insulin [Pharmacology Research] Objective: 1- To compare the efficacy, safety and health related quality of life of patients using Jusline insulin vs patients using other types of insulin 2- To determine the optimum therapeutic dose of Jusline insulin in patients with IDMM and NIDMM
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Clinical study for evaluation of efficacy of Easyef on diabetic foot ulcers [Pharmacology Research] Objective: 1 Evaluation of efficacy: Evaluation of decrease of ulcer area Initially, the difference of ulcer areas before and after treatment is evaluated 2
Evaluation of adverse effects: For evaluation of systemic adverse effects of test drug, data are collected as mentioned below in the methodology 3 Evaluation of safety: Safety is evaluated in all subjects who received at least one administration of study medication The mechanism of evaluation of safety is mentioned in details below in the methodology
LAF 237 vildagliptin effect on type 2 diabetic Saudi patients manged with diet and exercise
Pharmacology Research Objective: To evaluate the pharmacological effect of LAF 237 on improving glycaemic control in Saudi diabetic population managed with diet and exercise and to identify the possible adverse effects that could happen in using this drug in that ethnic group prior to FDA approval distribution in the kingdom
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A Phase III, Randomized, Active Comparator pioglitazone Controlled Clinical Trial to Study the Safety and Efficacy of sitagliptine MK-0431A A Fixed Dose Combination tablet of sitagliotine and metformin in Patients With Type 2 Diabetes Mellitus
Pharmacology Research Objective: Primary objective: To assess the effect of a FDC fixed dose combination of sitagliptin/metformin 50/1000 mg bid
compared with the effect of a FDC of pioglitazone mg qd on HbA1cat week 40 To assess the HbA1 c lowering efficancy of treatment with sitagliptin after 12 weeks To assess the safty and tolerability of sitagliptin and the fixed dose combination sitagliptin /metformin MK-0431A Secondary objective: To assess the effect of the fixed dose combination sitagliptin/ metformin 50/1000mg b i d comperd with the effect of pioglitazone 45 mg q d on the proporation of patients achieving glycemic goals HbA1c 70 , 65 To assess the effect of the fixed dose combination sitagliptin /metformin 50/1000mg b i d compared with the effect of pioglitazone 45 mg qd on 2 hour post parndial glucose PPG as determind by MTT at week 40 To assess the effect of the fixed dose combination sitagliptin / metformin MK0431 A 50/1000mg bid on FPG COMPERD TO PIOGLITAZONE 45MG QD AT WEEK 40 To assess the effect of sitagliptin on 2 hour post paran 
dial glucose as determind by meal compared to baseline after 12 week s To asses the effect of sitagliptin on FPG
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TO ASSES THE EFFECT OF SITAGLIPTIN /METFORMIN 50/1000mg bid on serum lipids including total cholesterol total C , LDL,
cholesterol LDL-C ,TG , and high density lipoprotein cholesterol hdl c compared to pioglitazone 45 mg q d
On-going Research in Nutrition
Sleep and its relation to obesity in Saudi students [Nutrition Research]
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Diabetic visual function study
[Supervised Research] Objective: To see if there is difference between diabetic patients without diabetic retinopathy control patient in color vision contrast sensitivity or not
Insulin prescribing practices in Saudi Arabia
[Supervised Research] The primary objectives are as follow: 1- To evaluate insulin prescribing at selected hospitals in Saudi Arabia 2- To describe the pattern magnitude of prescription errors associated with insulin therapy 3- To determine associated risk to patients from such errors 4- To propose writing tips to improve insulin-prescribing practices by clinicians
The secondary objectives are as follows: 1- To describe other types of medication prescribed to diabetes in the study population 2- To estimate the overall cost of drug therapy in patients who are on insulin therapy
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Effect of metformin on serum vitamin B12 in patients with type 2 DM in Saudi
Arabia
[Supervised Research] Objective: The aim of this study is to assess vitamin B12 status of patients with type 2 diabetes treated with metformin and to assess the need for monitoring of its level within these patients
The effect of Oral Magnesium Oxide supplements on plasma insulin glucose metabolism of type 2 diabetics in KAUH in Riyadh
Objective: The aim of this study is to evaluate the effect of oral magnesium oxide supplementation as magnesium oxide daily on plasma magnesium, insulin metabolic control in type 2 diabetic subjects in Saudi Arabia [Supervised Research]
Prevalence pattern of hyperlipidemia among Saudi pregnant diabetic women
Objective: 1- To estimate prevalence of hyperlipidemia among Saudi pregnant diabetic women 2- To find the pattern of hyperlipidemia among the same population 3- To study the associated risk factors with developing hyperlipidemia among the same group of patients Supervised Research
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Clinical predictors of Ischemic heart diseases in diabetic patients
Objective: To study the clinical predictors of coronary heart disease in diabetics with established diseases Supervised Research
Urinary tract infection among
diabetic patients
Supervised Research Objective: To evaluate the incidence and prevalence of the UTI in diabetic patients, and the risk of UTI and asymptomatic bacteriuria in relation to DM, to determine the clinical characteristics, risk factors, causative organism and the consequences on renal function and diabetic patients
Pedographis changes post anodyne therapy in diabetic peripheral neuropathy
Objective: This study aim to investigate the effect of anodyne therapy in treatment on both seanstion pain in the feet of patients with DPN, also to investigate the effect of ATS on the planter presser by using pedography Supervised Research
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Serum adipocytikines concentration in obese normal teen age Saudi girls effect of calorie intake sleeping pattern
Supervised Research Objective: To determine serum adipocytokines concentratin in obese control teen age Saudi girls An association between serum adipocytokines and sleeping pattern dietary intake of macronutrients such as total calories, fat, protein and carbohydrate in both control obese teen-age girls
Dental and mouth hygiene in type I diabetic children
Supervised Research Objective: To evaluate the
health care of the patient their family and to improve their knowledge
Prevalence of hypothyroidism in Saudi children with type I DM
Supervised Research Objective: To study the prevalence of hypothyroidism among Saudi children with type I diabetes mellitus and its determinants
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Hemostatic and firbrinolytic profile in type 2 diabetes mellitus effect on the incidence and severity of diabetic complications
Supervised Research Objective: The purpose of the current research proposal is to determine whether the platelets activation status and both the hemostatic and fibrinolytic systems activation levels are independent risk factors affecting the occurrence and severity of vascular complications in patients with DM2 To accomplish this, we are aiming at the following objectives: To define the hemostatic and fibrinolytic profile in patients with noncomplicated DM2 To define the hemostatic and fibrinolytic profile in various groups of complicated DM2 To compare between the diabetic and non-diabetic groups, as well as between the nomcomplicated and complicatied diabetic groups as regards the coagulopathy profile To compare between the various groups of
complicated DM2 as regards the coagulopathy profile To compare between the various severity stages within the same group of complicated DM2 as regards the coagulopathy profile To relate the results of this study to the results of other research teams, whether supporting or opposing, with interpretation of possible reasons in both cases
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Cytokines profile of T helper lymphocytes in Diabetic Patients Correlation with Markers of Obesity, and Hormonal Status
Supervised Research Objective: To determine the T helper cell indices as differentiating phenotypes in diabetic patients both complicated cases and controlled cases To measure markers of inflammation, and of adiposity, and in female diabetics the hormonal status To statistically analyze the previous measurements to determine the type of relation between these markers and between the clinical conditions of the patients involved in the study
Inflammation,
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Participated Conferences
The first International of Gulf Group Study of Diabetes In Dubai, UAE Second Arab Conference on Obesity Physical Activity In Bahrain 41th Annual Meeting of the European Associations for the Study of
Diabetes In Athens 2nd International Gulf Group for the Study of Diabetes Conference Muscat, Sultanate of Oman 15th European Congress on Obesity Budapest, Republic of Hungary 2nd International Congress on Prediabetes and the Metabolic Syndrome Barcelona, Spain
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Papers Published
WasimH, Al-Daghri NM, Chetty R, McTernan PG, Barnett AH, and Kumar S Relationship of serum and resistin to glucose intolerance and fat topography in South 10-Asians Cardiovasc Diabetol 2006; 5 Al-Daghri NM The association of endothelial constitutive nitric oxide synthase polymorphisms with family history of coronary heart disease in men Gene Ther Mol Biol 198-2006; 10: 193 Al-Daghri NM Hyperhomocystenemia, coronary heart disease, and diabetes mellitus as predicted by various definitions for metabolic syndrome in a hypersensitive Saudi 46-population, Saudi Med J 2007; 283: 339 Al-Daghri NM, Al-Attas OS, Al-Rubeaan K The atherogenic and metabolic impact on non-HDL cholesterol versus other lipid subcomponents among nondiabetic and diabetic Saudis Lipids health Dis 2007; 61:9 Al-Daghri NM, Al-Attas O, Al-Rubeaan K, mahieldin M, Al-Katari M, Jones AF, Kumar S Serum leptin its
association to antropometric measures of obesity in prediabetic Saudis Cardiovasc Diabetol 2007; 6:18 Al-Daghri NM, Al-Attas O, Al-Rubeaan K, Sallam R Adipocytokine profile of type 2 diabetics in metabolic syndrome as defined by various criteria Diabet Metab Res Rev [2007; Jul 26 [Epub ahead print Alsmadi O, Al-rubeaan K, Wakil SM, Imtiaz F, Mohamed G, Al-Saud H, Al-Saud NA, Al-Daghri N, Mohammad S, Meyer BF, Genetic Study of Saudi Diabetes GSSD: significant association of the KCNJ11 E23K polymorphism with type 2 diabetes Diabetes Metab Res Rev 2007; Oct 5 [Epub ahead print]
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