Diabetes Care 24:2054-2058. Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. Diabetes 54:909-914. …
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|BIOGRAPHICAL SKETCH |
|Provide the following information for the key personnel in the order listed on Form |
|Page 2 |
|Follow the sample format for each person DO NOT EXCEED FOUR PAGES |
| |
|NAME |POSITION TITLE |
|Craig L Hanis | |
| |Professor |
|eRA COMMONS USER NAME | |
|CHANIS | |
|EDUCATION/TRAINING Begin with baccalaureate or other initial professional |
|education, such as nursing, and include postdoctoral training |
|INSTITUTION AND LOCATION |DEGREE |YEARs |FIELD OF STUDY |
| |if |
| |
| |applicable| | |
|Brigham Young University, Provo, Utah |BS |1974 |Zoology |
|Brigham Young University, Provo, Utah |MS |1977 |Zoology |
|University of Michigan, Ann Arbor, |MA |1981 |Statistics |
|Michigan | | | |
|University of Michigan, Ann Arbor, |PhD |1981 |Human Genetics |
|Michigan | | | |
A Positions and Honors
Research Instructor, Graduate School of Biomedical Sciences, The University
of Texas Health Science Center at Houston, 9/1/81 - 8/31/83
Assistant Professor, Graduate School of Biomedical Sciences and School of
Public Health, The University of Texas Health Science Center at
Houston, 9/1/83 - 8/31/87
Associate Professor, Graduate School of Biomedical Sciences and School of
Public Health, The University of Texas Health Science Center at
Houston, 9/1/87 - 8/31/90
Acting Director,
Center for Demographic and Population Genetics and Medical
Genetics Center, The University of Texas Health Science Center at
Houston, 11/1/90 - 12/31/91
Professor, Genetics and Epidemiology, Human Genetics Center, School of
Public Health, The University of Texas Health Science Center at
Houston, 9/1/91 - present
John P McGovern Outstanding Teacher, Graduate School of Biomedical
Sciences - 1992
NIH - Research Career Development Award - 1987-1992
NIH - Member, Epidemiology and Disease Control 1 Study Section - 1998 -
2002
B Selected peer-reviewed publications in chronological order
Hanis CL, Sing CF, Clarke WR, and Schrott HG 1983 Multivariate models
for human genetic analysis: Aggregation, coaggregation and tracking
for systolic blood pressure and weight Am J Hum Genet 35:1196-1210
Hanis CL, Ferrell RE, Barton SA, Aguilar L, Garza-Ibarra A, Tulloch BR,
Garcia CA, Schull WJ 1983 Diabetes among Mexican-Americans in Starr
County, Texas Am J Epidemiol 118:659-672
Weiss KW, Ferrell RE, and Hanis CL 1984 A new world syndrome of
metabolic diseases with a genetic and
evolutionary basis Yearbook of
Physical Anthropology 27:153-178
Stunkard A, Sorensen TIA, Hanis CL, Teasdale TW, Chakraborty R, Schull WJ,
and Schulsinger F 1986 An adoption study of human obesity New
Engl J Med 314:193-198
Hanis CL, Chakraborty RC, Ferrell RE, Schull WJ 1986 Individual
admixture estimates: Disease associations and individual risk of
diabetes gallbladder disease Am J Phys Anthro 70:433-441
Schull WJ, Hanis CL 1990 Genetics and public health in the 1990s Ann
Rev Publ Health 11:105-25
Hanis CL, Hewett-Emmett D, Bertin TK, Schull WJ 1991 The origins of US
Hispanics: Implications for diabetes Diabetes Care 14:618
Hanis CL, Chu HH, Lawson K, Hewett-Emmett D, Barton SA, Schull WJ, Garcia
CA 1993 Mortality of Mexican-Americans with NIDDM: retinopathy and
other predictors in Starr County, Texas Diab Care 16:82-89
Hanis CL, Boerwinkle E, , Concannon P, , Spielman RS, , Bell GI
1996 A genome-wide search for human non-insulin-dependent type 2
diabetes genes reveals a major susceptibility locus on chromosome 2
Nature Genetics 13:161-167
Brown S, Hanis CL 1994
Effects of a culturally sensitive diabetes
education program among Hispanics with NIDDM from Starr County Texas
Diabetes Educator 213:203-210
Hanis CL 1997 Power considerations in the genetics of diabetes Diabetes
Reviews 5:270-276
Brown SA, Hanis CL 1999 Culturally Competent Diabetes Education for
Mexican Americans: The Starr County Study Diab Educator 252:226-
236
Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A
1999 Loci on chromosomes 2 NIDDM1 and 15 interact to increase
susceptibility to Type 2 diabetes in Mexican Americans Nature Genet
21:213-215
Horikawa Y, Oda N, Cox NJ, , Oda Y, Polonsky KS, Wei S, Concannon P,
Iwasaki N, Boerwinkle E, Hanis CL, Bell GI 2000 Identification of a
novel calpain-like cysteine protease as the major type 2 diabetes
mellitus susceptibility gene in Mexican Americans Nature Genetics
26:163-175
Sreenen SK, Zhou YP, Otani K, Hansen PA, Currie KPM, Pan CY, Lee JP,
Ostrega DM, Pugh W, Horikawa Y, Cox NJ, Hanis CL, Burant CF, Fox AP,
Bell GI, Polonsky KS 2001 Calpains play a role in insulin
secretion
and action Diabetes 50:2013-2020
Cuasay L, Lee ES, Oroander PP, Steffen-Batey L, Hanis CL 2001 Prevalence
and determinants of type 2 diabetes among Filipino Americans in the
Houston Metropolitan Statistical Area, Texas Diabetes Care 24:2054-
2058
Elbein SC, Chu W, , Hemphill C, Schay J, Cox NJ, Hanis CL, Hasstedt SJ
2002 Role of calpain-10 gene variants in familial type 2 diabetes
in Caucasians J Clin Endocrin Metab 87:650-4, 2002
The FBPP Investigators 2002 Multi-center genetic study of hypertension:
The Family Blood Pressure Program FBPP Hypertension 39:3-9
Poston WS, Haddock CK, Spertus J, Catanese DM, Pavlik VN, Hyman DJ, Hanis
CL, Foreyt JP 2002 Physical activity does not mitigate G-protein-
related genetic risk for obesity in individuals of African descent
Eating Weight Disorders 71:68-71
Wu X, Cooper RS, Borecki I, Hanis C, Bray M, Lewis CE, Zhu X, Kan D, Luke
A, Curb D 2002 A combined analysis of genomewide linkage scans for
body mass index from the NHLBI Family Blood Pressure Program American
Journal of Human Genetics 705:1247-56
Barkley RA, Brown AC, Hanis
CL, Kardia SL, Turner ST, Boerwinkle E 2003
Lack of genetic linkage evidence for a trans-acting factor having a
large effect on plasma lipoprotein[a] levels in African Americans J
Lipid Research 447:1301-5 Barkeley, RA, Chakravarti A, Cooper RS,
Ellison RC, Hunt SC, Province MA, Turner ST, Weder AB, Boerwinkle E,
on behalf of the Family Blood Pressure Program 2004 Positional
identification of hypertension susceptibility genes on chromosome 2
Hypertension 43part 2:477-482
Daniels PR, Kardia SL, Hanis CL, Brown CA, Hutchinson R, Boerwinkle E,
Turner ST 2004 Genetic Epidemiology Network of Arteriopathy study
Familial aggregation of hypertension treatment and control in the
Genetic Epidemiology Network of Arteriopathy GENOA study Am J Med
116:676-681
Bosque-Plata L, Aguilar-Salinas CA, Tusié-Luna MT, Ramírez-Jimenez S,
Rodriguez-Torres M, Aurón-Gómez M, Ramírez E, Velasco-Pérez ML,
Ramírez-Silva A, Gómez-Pérez F, Hanis CL, Tsuchiya T, Yoshiuchi I, Cox
NJ, Bell GI 2004 Association of variation in calpain-10 with type 2
diabetes mellitus in a Mexican
population Mol Gene Metab 81:122-
126
An P, Freedman BI, Hanis CL, Chen Yi, Weder AB, Schork Nj, Boerwinkle E,
Province MA, Hsiung CA, Wu X, Quertermous T, Rao DC 2005 Genome-
wide linkage scans for fasting glucose, insulin, and insulin
resistance in the NHLBI Family Blood Pressure Program Diabetes 54:909-
914
Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosley T, Gu CG, Tang H,
Rao DC, Risch N, Weder A 2005 Admixture mapping for hypertension
loci with genome-scan markers Nature Genetics 37:177-188
Hallman DM, Huber JC, Gonzalez VH, Klein BEK, Klein R, Hanis CL 2005
Familial aggregation of severity of diabetic retinopathy in Mexican
Americans from Starr County Diab Care 28:1163-68
Brown SA, Blozis SA, Kousekanani K, Garcia AA, Winchell M, Hanis CL 2005
Dosage effects of diabetes self-management education for Mexican
Americans: The Starr County Border Health Initiative Diab Care 28:527-
532
Cooper SP, Burau KE, Frankowski R, Shipp EM, del Junco DJ, Whitworth RE,
Sweeney AM, MacNaughton N, Weller NF, Hanis CL 2005 A Cohort Study
of Injuries in Migrant
Farmworker Families in South Texas Annals of
Epidemiology in press
Hayes MG, del Bosque-Plata L, Tsuchiya T, Hanis CL, Bell GI, Cox NJ 2005
Patterns of linkage disequilibrium in the type 2 diabetes gene capain-
10 Diabetes 54:3573-3576
Klos KL, Kardia SL, Hixson JE, Turner ST, Hanis C, Boerwinkle E, Sing CF
2005 Linkage analysis of plasma ApoE in three ethnic groups:
multiple genes with context-dependent effects Ann Hum Genet 69:157-
167
Clark VJ, Cox NJ, Hammond M, Hanis CL, Di Rienzo A 2005 Haplotype
structure and phylogenetic shadowing of a hypervariable region in the
CAPN10 gene Human Genetics 117:258-266
Kraja AT, Rao DC, Weder AB, Cooper R, Curb JD, Hanis CL, Turner ST, de
Andrade M, Hsiung CA, Quertermous T, Zhu X, Province MA 2005 Two
major QTLs and several others relate to factors of metabolic syndrome
in the family blood pressure program Hypertension 46:751-757
Hanis CL, Hallman D 2006 Genetics of diabetic retinopathy Current
Diabetes Reports 62:155-161
Tang H, Jorgenson E, Gadde M, Kardia SLR, Rao DC, Zhu X, Schork NJ, Hanis
CL, Risch N 2006 Racial
Admixture and its Impact on BMI and Blood
Pressure in African and Mexican Americans Human Genetics in press
Tsuchiya T, Schwartz PEH, del Bosque-Plata L, Hayes MG, Dina C, Froguel P,
Towers GW, Fisher S, Temelkova-Kurktschiev T, Rietzsch H, Graessler J,
Vcelak J, Palyzova D, Selisko T, Benlova B, Schulze J, Julius U,
Hanefeld M, Weedon MN, Evans JC, Frayling TM, Hattersley AT, Orho-
Melander M, Groop L, Malecki MT, Hansen T, Pedersen O, Fingerlin TE,
Boehnke M, Hanis CL, Cox NJ, Bell GI 2006 Association of the
calpain-10 gene with type 2 diabetes in Europeans: Results of pooled
and meta-analyses Molecular Genetics and Metabolism in press
Hallman DM, Boerwinkle E, Gonzalez VH, Klein BEK, Klein R, Hanis CL 2007
A genome-wide linkage scan for diabetic retinopathy susceptibility
genes in Mexican Americans with type 2 diabetes from Starr County,
Texas Diabetes in press
C Research Support
ONGOING
University of Texas PI 09/01/89 - 08/31/07 State of Texas
Starr County Diabetes Related Service Activities
The purpose of this project is to provide chronic disease screening in
the Texas/Mexico Border area; specifically Starr County
EY12386 PI 01/01/99 - 08/31/09 NIH/NEI
Genetics of Diabetic Retinopathy
The purpose of this project is to identify the genes involved in the
complications of diabetes with special focus on diabetic retinopathy
U01HL084715 Subcontract PI 06/15/06 - 05/31/09 NIH/NHLBI
Genome-Wide Association Mapping of Metabolic, Lung and Cardiovascular
Phenotypes
This is one of 11 projects funded under the NHLBIs RFA titled
Design and Analysis of Genome-wide Association Studies RFA HL-05-011
now referred to as ENDGAME Enhancing Development of Genome-wide
Association Methods It purpose is to develop and disseminate methods
for analyzing genome-wide association level data The purpose of this
subcontract to the University of Chicago where the PI is Dr Nancy J
Cox is to participate in the development of methods related to
biological pathways and also in the analysis genome wide data obtained on
cases and cohort members from Starr County, Texas
DK071100 Subcontract PI 04/01/06 - 03/31/11 NIH/NIDDK
Mapping T2DM Genes in
GENNID Families
The purpose of this project is to perform a genome-wide linkage scan
using approximately 7,000 SNPs using the multi-centered data resource
collected by the American Diabetes Association involving more than 6,000
individuals This is a collaborative effort between Dr Hanis and Dr
Steven Elbein from the University of Arkansas
NIH/NHGRI CEGS Co-investigator 07/01/01 - 06/30/07 NIH
Genomic Approaches to Common Chronic Disease
Develop evolutionary-population genetic methods for identifying subsets
of sites to be used in genotyping-phenotyping studies and apply these
strategies for predicting metabolic and physiologic measures of health in
African-American and non-Hispanic European-American populations
JDRF Subcontract PI 09/01/04 - 03/31/07 JDRF
Genetics of Retinopathy in Type 1 Diabetic African Americans
The purpose of this project is to examine the impact of variation in
diabetic retinopathy candidate genes on risk and progression of
retinopathy The principal investigator of this project is Dr Monique
Roy at the University of Medicine and Dentistry of New Jersey
HL054481 Co-investigator 09/01/05 - 08/31/08 NIH/NHLBI
The Family Blood Pressure Program
This project is for the continued follow-up of the Family Blood Pressure
program data resources
NCMHD Core PI 02/01/03 - 01/31/08 NIH
Creation of a Hispanic Health Research Center in the Lower Rio Grande
Valley: Diabetes Core This project is to develop a research core related
to type 2 diabetes in the Lower Rio Grande Valley of Texas
DK073286 Subcontract PI 09/15/06 - 08/31/08 NIH/NIDDK
Integrating Education, Group Support and Case Management for Diabetic
Hispanics
The purpose of this project is to develop culturally and community
sensitive methods for integrating diabetes case management as a strategy
for improving blood glucose control among Mexican Americans in Starr
County, Texas
COMPLETED
DK47487 PI 09/30/93 - 08/31/06 NIH/NIDDK
NIDDM Genes in Hispanics, Blacks and Non-Hispanic Whites
The purpose of this project is to locate the genes responsible for
susceptibility to NIDDM
HL54504 PI 06/01/95 - 08/31/06 NIH/NHLBI
Genes and High BP: Mexican American Field Center
This is one of 3 field centers to generate data for identifying genes
contributing to blood pressure
