animals with experimentally-induced diabetes often suffer from neuropathic pain. Additionally, diabetes is frequently associated with a reduction in the pain …
Title:
Continuous Exposure to Macronutrient Selection Improves Morphines
Analgesic Actions in Rats with Streptozotocin-Induced Diabetes | |
|Authors: |
|Monica Leibovici, Wendy Foulds-Mathes, Robin Kanarek |
|Presented by: |
|Monica Leibovici |
|Departments: |
|Department of Psychology, Tufts University School of Arts and Sciences |
Abstract:
Both diabetic patients and animals with experimentally-induced diabetes
often suffer from neuropathic pain Additionally, diabetes is frequently
associated with a reduction in the pain relieving properties of opiate
drugs Previous work has shown that rats allowed to self-select their diet
from separate sources of protein, fat and carbohydrate display milder
symptoms of diabetes after injections of the diabetogenic drug,
streptozotocin STZ than rats given a single laboratory diet The results
of these experiments suggest that allowing diabetic rats to self-select
their diets
may lessen neuropathic pain and increase sensitivity to
morphine To test these suggestions, male Long-Evans rats were fed either
separate sources of macronutrients or a composite diet for four weeks The
rats then were injected with either 45 mg/kg STZ ip or buffer solution
Half of the diabetic rats and half of the controls were maintained under
the same dietary condition, while the other half were switched to the other
dietary condition Food and water intakes, body weights, and blood glucose
were measured throughout the experiment Four weeks after STZ injections,
hot water tail withdrawal was used to test morphine-induced analgesia Rats
given STZ displayed hyperglycemia in all diet conditions except those
maintained on the diet selection regime throughout the study Additionally,
no differences in morphine-induced antinociception between diabetic rats
and controls were observed in rats continuously fed the diet selection
components In contrast, diabetic rats in the other three dietary
conditions were less sensitive to the pain relieving actions of morphine
than their non-diabetic counterparts These results suggest that allowing
animals to self select their diet protects against the
effects of STZ-
induced diabetes
Source:tufts.edu
