and prevention of type 1 diabetes. TrialNet is conducting three types of research: If you wish to be tested for diabetes risk, but do …
Intervention Studies in Newly Diagnosed Diabetes
The goal of these research studies is to preserve insulin secretion in people newly diagnosed with type 1 diabetes Eligible participants will be randomly like the flip of a coin put into either an experimental treatment group or a control group The experimental group will receive the new treatment and the control group will receive a pretend treatment Differences between the two groups will help researchers know if the experimental treatment is successful Ongoing intervention studies will be available at specific TrialNet sites located at medical institutions in the United States and Canada
WHAT IS TYPE 1 DIABETES?
Type 1 diabetes is a life-long disease that can affect both children and adults It occurs when the body attacks and destroys the cells in the pancreas that make insulin The body needs insulin, which is a hormone required to use food for energy
TO GET A REFERRAL TO A TRIALNET SITE, CALL TOLL FREE
1-800-HALT-DM1
1-800-425-8361
You will then receive: A phone evaluation to find out if you might be eligible for any current TrialNet studies A referral to the closest clinical site in your area
Type1Diabetes
RESEARCH
STUDIES?
DO YOU WANT TO LEARN MORE ABOUT
WHAT IS TYPE 1 DIABETES TRIALNET?
Type 1 Diabetes TrialNet is a network of 18 clinical centers dedicated to conducting diabetes prevention research and studying intervention therapies for children and adults with newly diagnosed diabetes TrialNet centers work in cooperation with screening sites located throughout the United States, Canada, Europe and Australia/New Zealand TrialNet researchers are experts in both diabetes and the bodys immune system They share common scientific goals related to the study, treatment, and prevention of type 1 diabetes TrialNet is conducting three types of research: Natural History Studies: These studies will enable us to learn more about risk factors associated with the development of type 1 diabetes Diabetes Prevention Studies: These studies will test therapies that may delay or prevent the onset of type 1 diabetes Diabetes Intervention Studies: These studies will test therapies to preserve insulin secretion in people recently diagnosed with type 1 diabetes
An information packet for the type of research that is of interest to you If you wish to be tested for diabetes risk, but do not live near a
TrialNet site, we will refer you to Clinical Center staff who will explain the screening process and provide you with a test kit to have your blood test performed locally by your own physician You may also learn about TrialNet at
wwwdiabetestrialnetorg
Information will be maintained in a confidential manner
WHO CAN PARTICIPATE IN INTERVENTION STUDIES?
You may be eligible to participate in a diabetes intervention study if you are:
Between the ages of 12 to 35 years of age Newly diagnosed with type 1 diabetes within the last 3 months
Type 1 Diabetes TrialNet is sponsored by the following organizations:
National Institute of Diabetes Digestive Kidney Diseases
NATIONAL INSTITUTES OF HEALTH
National Institute of Allergy and Infectious Diseases
NATIONAL INSTITUTES OF HEALTH
WHY SHOULD YOU PARTICIPATE IN AN INTERVENTION STUDY?
You will be a part of a research study to learn if it is possible to save remaining insulin production after a diagnosis of diabetes If the intervention is successful, your diabetes may be easier to manage, possibly reducing your risks of abnormal blood sugar levels and long-term complications
Initial Screening for Risk of Developing Diabetes
TrialNet is
screening relatives of people with type 1 diabetes to find out if these family members are at risk for developing diabetes [IF YOU ALREADY HAVE DIABETES, SEE THE SECTION ABOUT INTERVENTION STUDIES] Screenin 
g involves a simple blood test for the presence of diabetes-related autoantibodies that may appear years before type 1 diabetes develops First-degree blood relatives siblings, children or parents who are 1 to 45 years of age as well as second-degree blood relatives cousins, uncles, aunts, nieces, nephews, grandparents or half-siblings who are 1 to 20 years of age may be screened to determine their risk of developing type 1 diabetes Note: A relative diagnosed before the age of 40 AND started on insulin within the first year of diagnosis probably has type 1 diabetes Relatives of people with type 1 diabetes have about a 3-4 percent chance of testing positive for autoantibodies associated with diabetes There is no cost for the test to be enrolled in either a Natural History or Prevention Study All research volunteers will be closely monitored for early detection of type 1 diabetes Early detection of type 1 diabetes may improve your blood sugar control and reduce your chances of
developing complications You will be part of a research program that may help other people at risk for type 1 diabetes
A Network of Clinical Sites Throughout the United States, Canada, Europe and Australia/New Zealand is Connected with the Following Clinical Centers:
California
Childrens Hospital Los Angeles Los Angeles, CA 888 835-3761 Stanford University Medical Center Stanford, CA 877 232-5182 University of California, San Francisco San Francisco, CA 415 514-3730
Massachusetts
Joslin Diabetes Center Childrens Hospital Boston Boston, MA 800 242-5836
Canada
The Hospital for Sick Children Toronto, Ontario 866 699-1899
Australia/New Zealand Minnesota
University of Minnesota Minneapolis, MN 800 688-5252, Ext 58944 Walter and Eliza Hall Institute of Medical Research Parkville, Victoria 61-3-93452555
NATURAL HISTORY STUDIES
Natural history studies are being done to learn more about what causes type 1 diabetes and to better define predictors of the disease process These studies provide close monitoring to individuals at risk for developing type 1 diabetes Individuals who qualify may be offered an opportunity to participate in a prevention study
New York
Naomi Berrie Diabetes
Center Columbia University New York, NY 212 851-5425
Finland
University of Turku Department of Pediatrics Turku, Finland 358-2-313 0000
Colorado
Barbara Davis Center for Childhood Diabetes University of Colorado Denver, CO 800 572-3992
Pennsylvania
Childrens Hospital of Pittsburgh of UPMC Pittsburgh, PA 412 692-5210
Italy
Vita-Salute San Raffaele University Milan, Italy 39-02-2643 2818
Florida
University of Florida Gainesville, FL 800 749-7424, dial 1, Ext 334-0857 University of Miami School of Medicine Miami, FL 305 243-3781
United Kingdom Texas
University of Texas Southwestern Medical Center at Dallas Dallas, TX 214 648-4844 University of Bristol Bristol, UK 44-117-959 5337
DIABETES PREVENTION STUDIES
Diabetes prevention studies are being planned to determine whether new therapies can delay, or prevent, the onset of type 1 diabetes in at-risk individuals If you are enrolled in a prevention trial, your development of diabetes may be delayed, or prevented, if the therapy being tested is successful Note: Eligibility criteria will vary for different diabetes prevention studies
HOW WILL YOU BENEFIT FROM SCREENING AND FURTHER RISK ASSESSMENT?
If you learn you are at risk for
developing type 1 diabetes, additional tests will be offered to estimate your chances of developing type 1 diabetes If you qualify, you may have an opportunity
Washington
Benaroya Research Institute at Virginia Mason Seattle, WA 800 888-4187
Indiana
Riley Hospital for Children Indiana University Indianapolis, IN 866 230-8486
Source:healthandage.com
